Zvinokonzera psoriasis zvinosanganisira genetic, immune, zvakatipoteredza uye zvimwe zvinhu, uye pathogenesis yayo haisati yanyatsojeka.
1. Genetic factors
Zvidzidzo zvakawanda zvakaratidza kuti genetic zvinhu zvinoita basa rakakosha pathogenesis ye psoriasis.Nhoroondo yemhuri yechirwere ichi inotora 10% kusvika 23.8% yevarwere muChina uye vanenge 30% kune dzimwe nyika.Mikana yekuve nemwana ane psoriasis ndeye 2% kana pasina mubereki ane chirwere, 41% kana vabereki vese vaine chirwere, uye 14% kana mubereki mumwe ane chirwere.Zvidzidzo zvemapatya ane hukama ne psoriasis zvakaratidza kuti mapatya e monozygotic ane mukana we 72% wekuva nechirwere panguva imwe chete uye dizygotic mapatya ane 30% mukana wekuve nechirwere panguva imwe chete.Zvinopfuura gumi zvinonzi susceptibility loci zvakaonekwa izvo zvine hukama zvakanyanya nekuvandudzwa kwe psoriasis.
2. Zvinhu zvinodzivirira muviri
Abnormal activation yeT-lymphocytes uye kupinda mukati epidermis kana dermis zvakakosha pathophysiological features of psoriasis, zvichiratidza kubatanidzwa kwemasimba ezvirwere mukukura nekufambira mberi kwechirwere.Zvidzidzo zvenguva pfupi yapfuura zvakaratidza kuti IL-23 kugadzirwa nemasero edendritic uye mamwe masero e-antigen-presenting (APCs) anokonzera kusiyanisa uye kupararira kweCD4 + mubatsiri T lymphocytes, masero eT17, uye masero akakura eTh17 anogona kuvhara zvakasiyana-siyana zveTh17-se-serura zvinhu zvakadai. se IL-17, IL-21, uye IL-22, iyo inokurudzira kuwandisa kwakanyanyisa kwemasero ekugadzira keratin kana kupindura kwekuputika kwemasero e synovial.Nokudaro, masero eT17 uye IL-23 / IL-17 axis inogona kuita basa rinokosha pathogenesis ye psoriasis.
3. Zvakatipoteredza uye Metabolic Factors
Zvinhu zvakatipoteredza zvinoita basa rinokosha mukukonzera kana kuwedzera psoriasis, kana kuti kuwedzera chirwere, kusanganisira zvirwere, kushungurudzika mupfungwa, tsika dzakaipa (semuenzaniso, kusvuta, kudhakwa), kushungurudzika, uye maitiro kune mamwe mishonga.Kutanga kwepitting psoriasis kunowanzobatanidzwa neacute streptococcal infection ye pharynx, uye anti-infection kurapwa kunogona kutungamirira pakuvandudza nekuderedza kana kuregererwa kwezvironda zveganda.Kushushikana mupfungwa (sekushushikana, kusagadzikana kwehope, kushanda zvakanyanya) kunogona kukonzera psoriasis kuitika, kuwedzera kana kudzokazve, uye kushandiswa kwekurapa kwepfungwa kunogona kuderedza mamiriro acho.Inowanikwawo kuti hypertension, chirwere cheshuga, hyperlipidemia, coronary artery chirwere uye kunyanya metabolic syndrome ine kupararira kwakanyanya pakati pevarwere vepsoriasis.
Nguva yekutumira: Mar-17-2023
