Zvinokonzera psoriasis zvinosanganisira majini, immune system, zvakatipoteredza nezvimwe zvinhu, uye pathogenesis yayo haisati yanyatsojeka.
1. Zvinhu zvinokonzerwa nemajini
Ongororo dzakawanda dzakaratidza kuti majini ane basa guru mukukura kwechirwere chepsoriasis. Nhoroondo yemhuri yechirwere ichi inoverengera 10% kusvika 23.8% yevarwere muChina uye vangangoita 30% kune dzimwe nyika.Mikana yekuva nemwana ane psoriasis ndeye 2% kana pasina mubereki ane chirwere ichi, 41% kana vabereki vese vane chirwere ichi, uye 14% kana mumwe mubereki aine chirwere ichi.Zvidzidzo zvemapatya ane chekuita nepsoriasis zvakaratidza kuti mapatya ane mukana we72% wekuva nechirwere ichi panguva imwe chete uye mapatya ane mukana we30% wekuva nechirwere ichi panguva imwe chete. Mapatya anopfuura gumi anonzi susceptibility locis akaonekwa ane chekuita zvakanyanya nekukura kwepsoriasis.
2. Zvirwere zvekudzivirira muviri
Kushanda zvisina kujairika kweT-lymphocytes uye kupinda mu epidermis kana dermis zvinhu zvakakosha pathophysiological zviratidzo zve psoriasis, zvichiratidza kubatanidzwa kwemasoja ekudzivirira muviri mukukura uye kufambira mberi kwechirwere.Ongororo dzichangobva kuitwa dzakaratidza kuti kugadzirwa kweIL-23 nemasero edendritic nemamwe masero anogadzira antigen (APCs) kunokonzera kusiyana uye kuwanda kweCD4+ helper T lymphocytes, masero eTh17, uye masero eTh17 akakura anogona kuburitsa zvinhu zvakasiyana-siyana zvakaita seTh17 zvakaita seIL-17, IL-21, uye IL-22, izvo zvinokurudzira kuwanda kwakanyanya kwemasero anoita keratin kana kupindura kwemasero esynovial kuzvimba. Nokudaro, masero eTh17 uye IL-23/IL-17 axis zvinogona kuita basa guru mukukura kwepsoriasis.
3. Zvinhu Zvinokonzera Kushanduka Kwemuviri Uye Zvezvakatipoteredza
Zvinhu zvinokonzeresa nharaunda zvine basa guru mukukonzera kana kuwedzera psoriasis, kana kuti kuwedzera nguva yechirwere ichi, kusanganisira hutachiona, kushushikana kwepfungwa, tsika dzakaipa (semuenzaniso, kusvuta, kudhakwa), kukuvara, uye maitiro emishonga.Kutanga kwe psoriasis ine pitting kunowanzobatanidzwa nehutachiona hwe streptococcal mu pharynx, uye kurapwa kwekudzivirira hutachiona kunogona kutungamira mukuvandudza nekuderedza kana kuregererwa kwemaronda eganda. Kushushikana kwepfungwa (kwakadai sekushushikana, matambudziko ekurara, kushanda zvakanyanya) kunogona kukonzera psoriasis kuitika, kuwedzera kana kudzoka, uye kushandiswa kwemishonga yepfungwa kunogona kuderedza dambudziko racho. Zvakawanikwawo kuti BP, chirwere cheshuga, hyperlipidemia, chirwere chemwoyo uye kunyanya metabolic syndrome zvine huwandu hwakanyanya hwevanhu vane psoriasis.
Nguva yekutumira: Kurume-17-2023
